* = Corresponding Author

43. Kilo-Scale Electrochemical Oxidation of a Thioether to a Sulfone: A Workflow for Scaling Up Electrosynthesis

C. Bottecchia,* Dan Lehnherr,* F. Lévesque, M. Reibarkh, Y. Ji, V. L. Rodrigues, H. Wang, Y.-h. Lam, T. P. Vickery, B. M. Armstrong, K. A. Mattern, K. Stone, M. K. Wismer, A. N. Singh, E. L. Regalado, K. M. Maloney, N. A. Strotman

Org. Process Res. Dev. 2022, ASAP. [PDF] doi: 10.1021/acs.oprd.2c00111

• Selected as ACS Editors' Choice (open acess for a limited time)


42. Parallel versus Twisted Pentacenes: Conformational Impact on Singlet Fission

I. Papadopoulos, S. R. Reddy, P. B. Coto*, D. Lehnherr, D. Thiel, M. Thoss, R. R. Tykwinski, D. M. Guldi*

J. Phys. Chem. Lett. 2022, 13, 5094—5100. [PDF] doi: 10.1021/acs.jpclett.2c01395


41. Efficient Aliphatic Hydrogen-Isotope Exchange with Tritium Gas through the Merger of Photoredox and Hydrogenation Catalysts

H. Yang,* Z. Huang, D. Lehnherr,* Y.-h. Lam, S. Ren, N. A. Strotman

J. Am. Chem. Soc. 2022, 144, 5010—5022. [PDF] doi: 10.1021/jacs.1c13265


40. Electrochemically Driven Cross-Electrophile Coupling of Alkyl Halides

W. Zhang, L. Lu, W. Zhang, Y. Wang, S. D. Ware, J. Mondragon, J. Rein, N. Strotman, D. Lehnherr, K. A. See,* S. Lin*

Nature 2022, 604, 292—297. [PDF] doi: 10.1038/s41586-022-04540-4


39. Photons or Electrons? A Critical Comparison of Electrochemistry and Photoredox Catalysis for Organic Synthesis

N. E. S. Tay, D. Lehnherr,* T. Rovis*

Chem. Rev. 2022, 122, 2487—2649. [PDF] doi: 10.1021/acs.chemrev.1c00384

• Part of special issue on "Photochemical Catalytic Processes".


38. Manufacturing Process Development for Belzutifan, Part 2: A Continuous Flow Visible Light-Induced Benzylic Bromination

C. Bottecchia,‡,* F. Lévesque,‡,* J. P. McMullen, Y. Ji, M. Reibarkh, F. Peng, L. Tan, G. Spencer, J. Nappi, D. Lehnherr, K. Narsimhan, M. K. Wismer, L. Chen, Y. Lin, S. M. Dalby ( = equal contribution)

Org. Proc. Res. Dev. 2022, 26, 516—524. [PDF] doi: 10.1021/acs.oprd.1c00240


37. Benzylic Photobromination for the Synthesis of Belzutifan: Elucidation of Reaction Mechanisms Using In Situ LED-NMR

Y. Ji,* C. Bottecchia, F. Lévesque, K. Narsimhan, D. Lehnherr, J. P. McMullen, S. M. Dalby, K.-J. Xiao, M. Reibarkh*

J. Org. Chem. 2022, 87, 2055—2062. [PDF] [Supporting Information] doi: 10.1021/acs.joc.1c01465


36. Unlocking the Potential of High-Throughput Experimentation for Electrochemistry with a Standardized Microscale Reactor

J. Rein, J. R. Annand, M. K. Wismer, J. Fu, J. C. Siu, A. Klapars, N. A. Strotman, D. Kalyani,* D. Lehnherr,* S. Lin*

ACS Cent. Sci. 2021, 7, 1347—1355. [PDF] [Supporting Information] doi: 10.1021/acscentsci.1c00328

• HTeChem is now available from Analytical Sales.


35. OPRD_cover Development of a Green & Sustainable Manufacturing Process for Gefapixant Citrate
(MK-7264) Part 3: Development of a One-Pot Formylation-Cyclization Sequence to the Diaminopyrimidine Core

K. Basu,* D. Lehnherr,* G. E. Martin, R. A. Desmond, Y.-h. Lam, F. Peng, J. Y. L. Chung, R. Arvary, M. A. Zompa, S.-W. Zhang, J. Liu, Z. E. X. Dance, P. Larpent, R. D. Cohen, F. J. Guzman, N. J. Rogus, M. J. Di Maso, H. Ren, K. M. Maloney

Org. Process Res. Dev. 2020, 24, 2462—2477. [PDF] [Supporting Information] doi: 10.1021/acs.oprd.0c00246

• Featured on Issue Cover


34. OPRD_cover Development of a Green & Sustainable Manufacturing Process for Gefapixant Citrate
(MK-7264) Part 2: Development of a Robust Process for Phenol Synthesis.

F. Peng,* G. R. Humphrey, K. Maloney, D. Lehnherr, M. Weisel, F. Lévesque, J. R. Naber, A. P. J. Brunskill, P. Larpent, S.-W. Zhang, A. Y. Lee, R. A. Arvary, C. H. Lee, D. Bishara, K. Narsimhan, E. Sirota, M. Whittington.

Org. Process Res. Dev. 2020, 24, 2453—2461. [PDF] [Supporting Information] doi: 10.1021/acs.oprd.0c00241

• Featured on Issue Cover


33. OPRD_cover Development of a Green & Sustainable Manufacturing Process for Gefapixant Citrate
(MK-7264) Part 1: Introduction and Process Overview.

H. Ren,* K. M. Maloney,* K. Basu, M. J. Di Maso, G. R. Humphrey, F. Peng, R. Desmond, D. A. L. Otte, E. Alwdi, W. Liu, S.-W. Zhang, S. Song, R. A. Arvary, M. A. Zompa, D. Lehnherr, G. E. Martin, H. Yao, D. Chang, A. E. Mohan, F. J. Guzman, L. Jellett, A. Y. Lee, G. Spencer, E. S. Fisher, J. R. Naber, H. Gao, S. Lohani, R. T. Ruck, L.-C. Campeau

Org. Process Res. Dev. 2020, 24, 2445—2452. [PDF] [Supporting Information] doi: 10.1021/acs.oprd.0c00248

• Featured on Issue Cover


32. Generic Enhanced Sub/Supercritical Fluid Chromatography: The Blueprint for Highly Productive and Sustainable Separation of Primary Hindered Amines

J. O. DaSilva,* D. Lehnherr, J. Liu, R. Bennett, I. A. H. Ahmad, M. Hicks, B. F. Mann, D. A. DiRocco, Erik L. Regalado*

ACS Sustainable Chem. Eng. 2020, 8, 6011—6021. [PDF] [Supporting Information] doi: 10.1021/acssuschemeng.0c00777


31. Synthesis of Sterically Hindered Primary Amines by Concurrent Tandem Photoredox Catalysis

M. C. Nicastri, D. Lehnherr,* Y.-h. Lam, D. A. DiRocco, T. Rovis*

J. Am. Chem. Soc. 2020, 142, 987—998. [PDF] [Supporting Information] doi: 10.1021/jacs.9b10871


30. Electrochemical Synthesis of Hindered Primary and Secondary Amines via Proton-Coupled Electron Transfer

D. Lehnherr,* Y.-h. Lam, M. C. Nicastri, J. Liu, J. A. Newman, E. L. Regalado, D. A. DiRocco, T. Rovis*

J. Am. Chem. Soc. 2020, 142, 468—478. [PDF] [Supporting Information] doi:10.1021/jacs.9b10870


29. Mechanistic Study of a Re-Catalyzed Monoalkylation of Phenols

D. Lehnherr,* X. Wang,* F. Peng, M. Weisel, M. Reibarkh, K. M. Maloney


28. Discovery of a Photoinduced Dark Catalytic Cycle Using in Situ LED-NMR Spectroscopy

D. Lehnherr,‡,* Y. Ji,‡,* A. J. Neel, R. D. Cohen, A. P. J. Brunskill, J. Yang, M. Reibarkh
( = equal contribution)

J. Am. Chem. Sci. 2018, 140, 13843—13853. [PDF] [Supporting Information] doi: 10.1021/jacs.8b08596


27. Alkyne Benzannulation Reactions for the Synthesis of Novel Aromatic Architectures

S. J. Hein, D. Lehnherr, H. Arslan, F. J. Uribe-Romo, W. R. Dichtel*

Acc. Chem. Res. 2017, 50, 2776—2788. [PDF] doi: 10.1021/acs.accounts.7b00385


26. Rapid Access to Substituted 2-Naphthyne Intermediates via the Benzannulation of Halogenated Silylacetylenes

S. J. Hein, D. Lehnherr, W. R. Dichtel*

Chem. Sci. 2017, 8, 5675—5681. [PDF] [Supporting Information] doi: 10.1039/c7sc01625e


25. Reductive Aromatization/Dearomatization and Elimination Reactions to Access Conjugated Polycyclic Hydrocarbons, Heteroacenes, and Cumulenes

J. L. Marshall, D. Lehnherr, B. D. Lindner, R. R. Tykwinski*

ChemPlusChem 2017, 82, 967—1001. [PDF] doi: 10.1002/cplu.201700168

• Part of special issue on "Novel Aromatics: From Synthesis to Applications".


24. Diazatetracenes Derived From the Benzannulation of Acetylenes: Electronic Tuning via Substituent Effects and External Stimuli

D. Lehnherr, J. M. Alzola, C. R. Mulzer, S. J. Hein, W. R. Dichtel*

J. Org. Chem. 2017, 82, 2004—2010. [PDF] [Supporting Information] doi: 10.1021/acs.joc.6b02840

• Highlighted in Synfacts


23. Synthesis, Physical Properties, and Chemistry of Donor/Acceptor Substituted Pentacenes

D. Lehnherr, M. Adam, A. H. Murray, R. McDonald, F. Hampel, R. R. Tykwinski*

Can. J. Chem. 2017, 95, 303—314. [PDF] [Supporting Information] doi: 10.1139/cjc-2016-0450

• Part of special issue dedicated to Prof. Reginald Mitchell.


22. Tautomerization and Dimerization of 6,13-Disubstituted Derivatives of Pentacene

M. Garcia-Borràs, A. Konishi, A. Waterloo, Y. Liang, Y. Cao, C. Hetzer, D. Lehnherr, F. Hampel, K. N. Houk,* R. R. Tykwinski*

Chem. Eur. J. 2017, 23, 6111—6117. [PDF] [Supporting Information] doi: 10.1002/chem.201604099

• Part of special issue on "Cooperative Effects in Chemistry".


21. Mechanism-Guided Development of Highly Active Bis-Thiourea Catalysts for Cooperative Anion-Abstraction Catalysis

C. R. Kennedy, D. Lehnherr, N. S. Rajapaksa, D. D. Ford, Y. Park, E. N. Jacobsen*
( = equal contribution)

J. Am. Chem. Soc. 2016, 138, 18122—18127. [PDF] [Supporting Information] doi: 10.1002/jacs.6b09205


20. Sequence-Defined Oligo(ortho-Arylene) Foldamers Derived from the Benzannulation of ortho(Arylene ethynylene)s

D. Lehnherr, C. Chen, Z. Pedramrazi, C. R. DeBlase, J. M. Alzola, I. Keresztes, E. B. Lobkovsky, M. F. Crommie,* W. R. Dichtel*

Chem. Sci. 2016, 7, 6357—6364. [PDF] [Supporting Information] doi: 10.1039/C6SC02520J

• Highlighted in Synfacts


19. Conformational Control of Chiral Amido Thiourea Catalysts Enables Improved Catalytic Activity and Enantioselectivity

D. Lehnherr, D. D. Ford, A. Bendelsmith, C. R. Kennedy, E. N. Jacobsen*

Org. Lett. 2016, 18, 3214—3217. [PDF] [Supporting Information] doi: 10.1021/acs.orglett.6b01435h

• Highlighted in Synfacts


18. Anion-Abstraction Catalysis: The Cooperative Mechanism of α-Chloroether Activation by Dual H-Bond Donors

D. D. Ford, D. Lehnherr, C. R. Kennedy, E. N. Jacobsen*

ACS Catal. 2016, 6, 4616—4620. [PDF] [Supporting Information] doi: 10.1021/acscatal.6b01384


17. On- and Off-Cycle Catalyst Cooperativity in Anion-Binding Catalysis

D. D. Ford, D. Lehnherr, C. R. Kennedy, E. N. Jacobsen*
( = equal contribution)

J. Am. Chem. Soc. 2016, 138, 7860—7863. [PDF] [Supporting Information] doi: 10.1021/6b04686


16. Solution-Based Intramolecular Singlet Fission in Cross-Conjugated Pentacene Dimers

J. Zirzlmeier, R. Casillas, S. R. Reddy, P. B. Coto, D. Lehnherr, E. T. Chernick, I. Papadopoulos, M. Thoss*, R. R. Tykwinski*, D. M. Guldi*

Nanoscale 2016, 8, 10113—10123. [PDF] [Supporting Information] doi: 10.1039/C6NR02493a


15. cej2015_cover_smallRegioselective Synthesis of Polyheterohalogenated Naphthalenes via the Benzannulation
of Haloalkynes

D. Lehnherr, J. M. Alzola, E. B. Lobkovsky, W. R. Dichtel*

Chem. Eur. J. 2015, 21, 18122—18127. [PDF] [Supporting Information] doi: 10.1002/chem.2001503418

• Featured on Issue Cover



14. Singlet Fission in Pentacene Dimers

J. Zirzlmeier, D. Lehnherr, P. B. Coto, E. T. Chernick, R. Casillas, B. Basel, M. Thoss*, R. R. Tykwinski*, D. M. Guldi*

Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 5325—5330 [PDF] [Supporting Information] doi: 10.1073/pnas.1422436112


13. Aryl Substitution of Pentacenes

A. R. Waterloo, A.-C. Sale, D. Lehnherr, F. Hampel, R. R. Tykwinski*

Beilstein J. Org. Chem. 2014, 10, 1692—1705 [PDF] [Supporting Information] doi: 10.3762/bjoc.10.178

•  Part of special issue on “Functionalized Carbon-Nanomaterials” (Guest Editor: Prof. Anke Krueger).


12. Isomerically Pure syn-Anthradithiophenes: Synthesis, Properties and FET Performance

D. Lehnherr, A. Waterloo, K. P. Goetz, M. M. Payne, F. Hampel, J. E. Anthony,* O. D. Jurchescu,* R. R. Tykwinski*

Org. Lett. 2012, 14, 3660—3663 [PDF] [Supporting Information] doi: 10.1021/ol301503k


11. Synthesis and Properties of Isomerically Pure Anthrabisbenzothiophenes

D. Lehnherr, R. Hallani, R. McDonald, J. E. Anthony,* R. R. Tykwinski*

Org. Lett. 2012, 14, 62—65 [PDF] [Supporting Information] doi: 10.1021/ol202843x


10. Oligomers and Polymers Based on Anthracene, Tetracene, Pentacene, Naphthodithiophene, and Anthradithiophene Building Blocks

D. Lehnherr, R. R. Tykwinski*

Aust. J. Chem. 2011, 64, 919—929 [PDF] doi: 10.1071/CH11169


9. A Modular Synthetic Approach to Conjugated Pentacene Di-, Tri-, and Tetramers

D. Lehnherr, A. H. Murray, R. McDonald, R. R. Tykwinski*

Angew. Chem. Int. Ed. 2010, 49, 6190—6194 [PDF] [Supporting Information] doi: 10.1002/anie.201000555


8. Oligomers and Polymers Based on Pentacene Building Blocks

D. Lehnherr, R. R. Tykwinski*

Materials 2010, 3, 2772—2800 [PDF] doi: 10.3390/ma3042772

• Review as part of the special issue on “Conjugated Oligomers” (Guest Editor: Prof. Herbert Meier).


7. Pentacene-Based Polycyclic Aromatic Hydrocarbon Dyads with Cofacial Solid-State Pi-Stacking

D. Lehnherr, A. H. Murray, R. McDonald, M. J. Ferguson, R. R. Tykwinski*

Chem. Eur. J. 200915, 12580—12584 [PDF] [Supporting Information] doi: 10.1002/chem.200902179


6. Pentacene Dendrimers: Synthesis and Thin Film Photoconductivity Measurements of Branched Pentacene Oligomers

D. Lehnherr, J. Gao, F. A. Hegmann,* R. R. Tykwinski*

J. Org. Chem. 2009, 74, 5017—5024 [PDF] [Supporting Information] doi: 10.1021/jo9007089


5. Synthesis of Soluble Oligo- and Polymeric Pentacene-Based Materials

D. Lehnherr, R. McDonald, M. J. Ferguson, R. R. Tykwinski*

Tetrahedron 2008, 64, 11449—11461 [PDF] [Supporting Information] doi: 10.1016/j.tet.2008.09.041

• Part of “The Synthesis of Carbon-Rich Nanomolecules” symposia in print.


4. Synthesis and Electronic Properties of Conjugated Pentacene Dimers

D. Lehnherr, J. Gao, F. A. Hegmann,* R. R. Tykwinski*

Org. Lett. 2008, 10, 4779—4782 [PDF] [Supporting Information] doi: 10.1021/ol801886h


3. Exploring Electronically Polarized Pentacenes

D. Lehnherr, R. McDonald, R. R. Tykwinski*

Org. Lett. 2008, 10, 4163—4166 [PDF] [Supporting Information] doi: 10.1021/ol801464k


2. Pentacene Oligomers and Polymers: Functionalization of Pentacene To Afford Mono-, Di-, Tri-, and Polymeric Materials

D. Lehnherr, R. R. Tykwinski*

Org. Lett. 2007, 9, 4583—4586 [PDF] [Supporting Information] doi: 10.1021/ol702094d


1. Formal Intramolecular Photoredox Chemistry of Meta-Substituted Benzophenones

D. Mitchell, M. Lukeman, D. Lehnherr, P. Wan*

Org. Lett. 2005, 7, 3387—3389 [PDF] [Supporting Information] doi: 10.1021/ol051381u


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